Patricia M Melville, NP

I began working at the Stony Brook University Multiple Sclerosis Comprehensive Care Center in 1994.  Both Dr Patricia Coyle and Dr Lauren Krupp were my mentors and taught me about multiple sclerosis.  The 1990’s were an amazing time in MS in that for the first time, therapies were being discovered.  I loved working with the patients and educating them about their disease and the various treatment options.  I felt that as a nurse, I could have a positive impact on the patients.  I went back to school for my graduate degree and became an Adult Nurse Practitioner.  The field of MS research has continued to grow exponentially.  I have been actively involved in MS research both industry sponsored clinical trials and investigator initiated studies.  I have obtained my MS Nursing Certification status.  I am currently on the board of the International Organization of MS Nurses.  I am the past president of the Long Island MS Nurses Society.  I have authored numerous journal articles for peer reviewed publications.  I have lectured nationally to MS patient groups as well as to peers at National and International MS meetings.  It is my very great privilege to continue to work with and for this patient population and help them in their journey with this devastating neurological disease.

Fluid Intake and Urinary Symptoms in Patients with Multiple Sclerosis.  Tam J, Gross MD, Cheung A, Melville PM, Kim JM, Weissbart SJ. J Urol. 2020 Dec;204(6):1284-1289. doi: 10.1097/JU.0000000000001309. Epub 2020 Jul 28. PMID: 32924823

Unemployment in multiple sclerosis: the contribution of personality and disease.  Strober LB, Christodoulou C, Benedict RH, Westervelt HJ, Melville P, Scherl WF, Weinstock-Guttman B, Rizvi S, Goodman AD, Krupp LB. Mult Scler. 2012 May;18(5):647-53. doi: 10.1177/1352458511426735. Epub 2011 Dec 19. PMID: 22183935

Multicenter randomized clinical trial of donepezil for memory impairment in multiple sclerosis. Krupp LB, Christodoulou C, Melville P, Scherl WF, Pai LY, Muenz LR, He D, Benedict RH, Goodman A, Rizvi S, Schwid SR, Weinstock-Guttman B, Westervelt HJ, Wishart H. Neurology. 2011 Apr 26;76(17):1500-7. doi: 10.1212/WNL.0b013e318218107a. PMID: 21519001 Free PMC article. Clinical Trial.

Donepezil improved memory in multiple sclerosis in a randomized clinical trial. Krupp LB, Christodoulou C, Melville P, Scherl WF, MacAllister WS, Elkins LE. Neurology. 2004 Nov 9;63(9):1579-85. doi: 10.1212/01.wnl.0000142989.09633.5a. PMID: 15534239 Clinical Trial.

Study and treatment of post Lyme disease (STOP-LD): a randomized double masked clinical trial. Krupp LB, Hyman LG, Grimson R, Coyle PK, Melville P, Ahnn S, Dattwyler R, Chandler B. Neurology. 2003 Jun 24;60(12):1923-30. doi: 10.1212/01.wnl.0000071227.23769.9e. PMID: 12821734 Clinical Trial.

High-dose cyclophosphamide for moderate to severe refractory multiple sclerosis: 2-year follow-up (investigational new drug No. 65863). Gladstone DE, Peyster R, Baron E, Friedman-Urevich S, Sibony P, Melville P, Gottesman M. Am J Ther. 2011 Jan;18(1):23-30. doi: 10.1097/MJT.0b013e3181b3ad95. PMID: 19770795

Cognitive performance and MR markers of cerebral injury in cognitively impaired MS patients. Christodoulou C, Krupp LB, Liang Z, Huang W, Melville P, Roque C, Scherl WF, Morgan T, MacAllister WS, Li L, Tudorica LA, Li X, Roche P, Peyster R. Neurology. 2003 Jun 10;60(11):1793-8. doi: 10.1212/01.wnl.0000072264.75989.b8. PMID: 12796533 Clinical Trial.

Negative affect predicts subsequent cognitive change in multiple sclerosis. Christodoulou C, Melville P, Scherl WF, Macallister WS, Abensur RL, Troxell RM, Krupp LB. J Int Neuropsychol Soc. 2009 Jan;15(1):53-61. doi: 10.1017/S135561770809005X. PMID: 19128528

Effects of donepezil on memory and cognition in multiple sclerosis. Christodoulou C, Melville P, Scherl WF, Macallister WS, Elkins LE, Krupp LB. J Neurol Sci. 2006 Jun 15;245(1-2):127-36. doi: 10.1016/j.jns.2005.08.021. Epub 2006 Apr 19. PMID: 16626752 Clinical Trial.

Perceived cognitive dysfunction and observed neuropsychological performance: longitudinal relation in persons with multiple sclerosis. Christodoulou C, Melville P, Scherl WF, Morgan T, MacAllister WS, Canfora DM, Berry SA, Krupp LB. J Int Neuropsychol Soc. 2005 Sep;11(5):614-9. doi: 10.1017/S1355617705050733. PMID: 16212689

Remotely-delivered cognitive remediation in multiple sclerosis (MS): protocol and results from a pilot study. Charvet LE, Shaw MT, Haider L, Melville P, Krupp LB. Mult Scler J Exp Transl Clin. 2015 Oct 5;1:2055217315609629. doi: 10.1177/2055217315609629. eCollection 2015 Jan-Dec. PMID: 28607707