William Y Guo, MD

My goal is to provide compassionate, patient-centered care while respecting each individual's values and goals when developing a treatment plan. I believe that every patient should have a clear understanding of their diagnosis and all available treatment options, including the benefits and potential drawbacks of each, so they can make informed decisions with confidence. I am trained to manage the full spectrum of Mohs surgery cases, including rare and complex tumors such as dermatofibrosarcoma protuberans, extramammary Paget disease, atypical fibroxanthoma, and other uncommon cutaneous malignancies. My reconstructive philosophy is to achieve the best possible functional and cosmetic outcome using the simplest effective technique whenever appropriate. I have extensive training in skin grafts, local flap reconstruction, and the use of skin substitutes.

In addition, I have significant experience treating advanced and high-risk skin cancers, particularly squamous cell carcinoma. I recognize when surgery alone is no longer the best option and work closely with multidisciplinary teams to incorporate emerging therapies, including immunotherapy, when they offer the greatest benefit for my patients.
 

• Rosacea and Its Association With Malignancy: Systematic Review.
  Thapa L, Xia J, Guo W, Usmani H, Miller D, Lozeau D.JMIR Dermatol. 2023 Nov 8;6:e47821. doi: 10.2196/47821.

• Low-dose oral minoxidil does not significantly affect blood pressure: A systematic review and meta-analysis.
  Chen M, Weichert M, Guo W, Ruzic R, Briley J.J Am Acad Dermatol. 2025 Mar;92(3):554-555. doi: 10.1016/j.jaad.2024.10.057. Epub 2024 Nov 7.
   
• Vitiligo and Metabolic Syndrome: Systematic Review and Meta-Analysis.
  Xia J, Melian C, Guo W, Usmani H, Clark R, Lozeau D.JMIR Dermatol. 2022 Mar 16;5(1):e34772. doi: 10.2196/34772.
   
• Association of Cellulitis With Obesity: Systematic Review and Meta-Analysis.
  Taira KG, Wang M, Guo W, Kam O, Kaufmann T.JMIR Dermatol. 2024 Aug 20;7:e54302. doi: 10.2196/54302.

• Effect of Dupilumab Therapy on Patch Test Results for Atopic Contact Dermatitis: A Systematic Review.
  Chu D, Tao K, Guo W, Briley J.Int J Dermatol. 2026 Apr;65(4):819-821. doi: 10.1111/ijd.70041. Epub 2025 Sep 1.
   
• Acral Persistent Papular Mucinosis in the United States: Case Series and Literature Review.
  Miller D, Manci R, Patel J, Guo W, Lozeau D, Briley J.JMIR Dermatol. 2025 Sep 16;8:e77714. doi: 10.2196/77714.
   
• Association between Psoriasis and MTHFR polymorphisms: a systematic review and meta-analysis.
  Matsuo R, Haught K, Guo W, Na S, Lu K, Kaufmann T, Siamas K.Arch Dermatol Res. 2024 May 21;316(5):184. doi: 10.1007/s00403-024-02905-5.
   
• Alternative uses of ustekinumab for non-indicated dermatological conditions: a systematic review.
  Rawal S, Kianian S, Guo W, Marquez J, Ayasse M, Siamas KA, Lee Y, Salvemini J.Arch Dermatol Res. 2022 Aug;314(6):503-514. doi: 10.1007/s00403-021-02262-7. Epub 2021 Jun 22.
   
• Frontal fibrosing alopecia and personal care product use: a systematic review and meta-analysis.
  Kam O, Na S, Guo W, Tejeda CI, Kaufmann T.Arch Dermatol Res. 2023 Oct;315(8):2313-2331. doi: 10.1007/s00403-023-02604-7. Epub 2023 Apr 4.

• A systematic review and meta-analysis of sexual dysfunction in patients with hidradenitis suppurativa.
  Varney P, Guo W, Brown M, Usmani H, Marquez J, Ayasse M, Kaufmann T, Haughton A. Int J Dermatol. 2023 Jun;62(6):737-746. doi: 10.1111/ijd.16328. Epub 2022 Jul 3. PMID: 35781695
   
• The uni-directional association of atopic dermatitis and rheumatoid arthritis: a systematic review and meta-analysis.
  Williams RC, Brako MYO, Guo W, Usmani H, Na S, Clark RAF. Arch Dermatol Res. 2023 Oct;315(8):2261-2269. doi: 10.1007/s00403-023-02619-0. Epub 2023 Apr 12. PMID: 37043009
   
• Asian American Vaccination, Testing, and Other Healthcare Knowledge & Behaviors during COVID-19, A Systematic Review.
  Anand S, Cao E, Kimura R, Guo W, Bassi N. Pathog Glob Health. 2023 Mar;117(2):120-133. doi: 10.1080/20477724.2022.2106110. Epub 2022 Jul 26. PMID: 35892162
   
• Prevalence of diabetes mellitus in bullous pemphigoid patients in the absence of dipeptidyl peptidase-4 inhibitors: a systematic review and meta-analysis.
  Guo W, Rathi S, Marquez J, Smith H, Kuruvilla A, Tonnesen MG, Salvemini JN. Arch Dermatol Res. 2023 Oct;315(8):2207-2213. doi: 10.1007/s00403-023-02562-0. Epub 2023 Mar 3. PMID: 36867222
   
• Hidradenitis Suppurativa in Psoriasis Patients Treated With Biologics.
  Chu D, Guo W, Chen M, Briley J. J Drugs Dermatol. 2026 Aug 1;25(8):e75-e76. doi: 10.36849/JDD.9592. PMID: 42555066
   
• Among the mimickers of Stevens-Johnson syndrome: A case of anasarca-induced skin desquamation.
  Manci R, Guo W, Chen M, Hugh J, Siamas K. JAAD Case Rep. 2024 Jul 6;51:72-74. doi: 10.1016/j.jdcr.2024.06.029. eCollection 2024 Sep. PMID: 39188330 
   
• Prevalence of female hirsutism and PCOS in the United States: A cross-sectional study.
  Chen M, Nguyen W, Haq Z, Guo W, Briley J. J Dtsch Dermatol Ges. 2025 Mar;23(3):330-338. doi: 10.1111/ddg.15630. Epub 2025 Jan 26. PMID: 39865752
   
• A case of mother and child with CANDLE syndrome: Diagnosis and subsequent treatment with baricitinib.
  Guo W, Lozeau D, Tonnesen M, Schuval S, de Jesus A, Miller D, Alehashemi S, Kristal L. Pediatr Dermatol. 2024 Nov-Dec;41(6):1162-1165. doi: 10.1111/pde.15667. Epub 2024 Jun 16. PMID: 38881047

• A case of dupilumab used to treat the exaggerated response to insect bites in the setting of chronic lymphocytic leukemia.
  Guo W, Miller D, Manci R, Korzenko A. JAAD Case Rep. 2024 Jan 17;45:56-58. doi: 10.1016/j.jdcr.2024.01.003. eCollection 2024 Mar. PMID: 38379876

• Predilection of acral lentiginous melanoma for sites of chronic mechanical stress: A meta-analytic review.  
  Guo W, Chen M, Dusza S, Marghoob A. J Am Acad Dermatol. 2026 Feb;94(2):656-658. doi: 10.1016/j.jaad.2025.09.102. Epub 2025 Oct 10. PMID: 41076130

• Reconstruction of a Beard-Bearing Chin Defect With Preservation of the Hair-Bearing Cosmetic Subunit. 
  Stolarczyk A, Guo W, Lambert Smith F. Dermatol Surg. 2026 Sep 23. doi: 10.1097/DSS.0000000000005354. Online ahead of print. PMID: 42771015