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Yusuf Hannun, MD
Hematology Oncology
Accepting New Patients
Highlights
Languages
- French
- Arabic
- English
Gender
MaleAbout Yusuf Hannun
Academic Title
Professor of Medicine & Pathology
Publications
- Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death.
Sundaram K | Mather AR | Marimuthu S | Shah PP | Snider AJ | Obeid LM | Hannun YA | Beverly LJ | Siskind LJ
The Biochemical journal
2016 Mar 15 - New role for ceramide in the pheromone response.
Matmati N | Kitagaki H | Hannun YA
Cell cycle (Georgetown, Tex.)
2016 Mar 3 - Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response.
Xu R | Wang K | Mileva I | Hannun YA | Obeid LM | Mao C
Oncotarget
2016 Mar 1 - ATRA transcriptionally induces nSMase2 through CBP/p300-mediated Histone acetylation.
Clarke CJ | Shamseddine AA | Jacob JJ | Khalife G | Burns TA | Hannun YA
Journal of lipid research
2016 Mar 24 - Aging-related elevation of sphingoid bases shortens yeast chronological life span by compromising mitochondrial function.
Yi JK | Xu R | Jeong E | Mileva I | Truman JP | Lin CL | Wang K | Snider J | Wen S | Obeid LM | Hannun YA | Mao C
Oncotarget
2016 Mar 19 - Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system.
Wang K | Xu R | Snider AJ | Schrandt J | Li Y | Bialkowska AB | Li M | Zhou J | Hannun YA | Obeid LM | Yang VW | Mao C
Cell death & disease
2016 - CHK1 regulates NF-kappaB signaling upon DNA damage in p53- deficient cells and associated tumor-derived microvesicles.
Carroll BL | Pulkoski-Gross MJ | Hannun YA | Obeid LM
Oncotarget
2016 Feb 22 - Analysis of the Involvement of Different Ceramide Variants in the Response to Hydroxyurea Stress in Baker's Yeast.
Chen PW | Fonseca LL | Hannun YA | Voit EO
PloS one
2016 - Substantial contribution of extrinsic risk factors to cancer development.
Wu S | Powers S | Zhu W | Hannun YA
Nature
2016 Jan 7 - Ceramide limits phosphatidylinositol-3-kinase C2beta-controlled cell motility in ovarian cancer: potential of ceramide as a metastasis-suppressor lipid.
Kitatani K | Usui T | Sriraman SK | Toyoshima M | Ishibashi M | Shigeta S | Nagase S | Sakamoto M | Ogiso H | Okazaki T | Hannun YA | Torchilin VP | Yaegashi N
Oncogene
2015 Sep 14 - Dynamics of the Heat Stress Response of Ceramides with Different Fatty-Acyl Chain Lengths in Baker's Yeast.
Chen PW | Fonseca LL | Hannun YA | Voit EO
PLoS computational biology
2015 Aug - Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase.
Airola MV | Allen WJ | Pulkoski-Gross MJ | Obeid LM | Rizzo RC | Hannun YA
Structure (London, England : 1993)
2015 Aug 4 - Activation of p38 Mitogen-Activated Protein Kinase in Gaucher's Disease.
Kitatani K | Wada M | Perry D | Usui T | Sun Y | Obeid LM | Yaegashi N | Grabowski GA | Hannun YA
PloS one
2015 - Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration.
Wu BX | Fan J | Boyer NP | Jenkins RW | Koutalos Y | Hannun YA | Crosson CE
PloS one
2015 - A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.
Salama MF | Carroll B | Adada M | Pulkoski-Gross M | Hannun YA | Obeid LM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2015 Jul - A new twist to the emerging functions of ceramides in cancer: novel role for platelet acid sphingomyelinase in cancer metastasis.
Hannun YA | Newcomb B
EMBO molecular medicine
2015 Jun - IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice.
Ghaleb AM | Bialkowska AB | Snider AJ | Gnatenko DV | Hannun YA | Yang VW | Schmidt VA
PloS one
2015 - GPR40/FFA1 and neutral sphingomyelinase are involved in palmitate-boosted inflammatory response of microvascular endothelial cells to LPS.
Lu Z | Li Y | Jin J | Zhang X | Hannun YA | Huang Y
Atherosclerosis
2015 May - Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis.
Rachidi S | Sun S | Wu BX | Jones E | Drake RR | Ogretmen B | Cowart LA | Clarke CJ | Hannun YA | Chiosis G | Liu B | Li Z
Journal of hepatology
2015 Apr - Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization.
Rajagopalan V | Canals D | Luberto C | Snider J | Voelkel-Johnson C | Obeid LM | Hannun YA
Biochimica et biophysica acta
2015 Apr - Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.
Adada MM | Canals D | Jeong N | Kelkar AD | Hernandez-Corbacho M | Pulkoski-Gross MJ | Donaldson JC | Hannun YA | Obeid LM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2015 Nov - P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest.
Shamseddine AA | Clarke CJ | Carroll B | Airola MV | Mohammed S | Rella A | Obeid LM | Hannun YA
Cell death & disease
2015 - Alkaline Ceramidase 3 Deficiency Results in Purkinje Cell Degeneration and Cerebellar Ataxia Due to Dyshomeostasis of Sphingolipids in the Brain.
Wang K | Xu R | Schrandt J | Shah P | Gong YZ | Preston C | Wang L | Yi JK | Lin CL | Sun W | Spyropoulos DD | Rhee S | Li M | Zhou J | Ge S | Zhang G | Snider AJ | Hannun YA | Obeid LM | Mao C
PLoS genetics
2015 Oct - Tumor Necrosis Factor-alpha (TNFalpha)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death.
Hernandez-Corbacho MJ | Canals D | Adada MM | Liu M | Senkal CE | Yi JK | Mao C | Luberto C | Hannun YA | Obeid LM
The Journal of biological chemistry
2015 Oct 16 - Elevation of 20-carbon long chain bases due to a mutation in serine palmitoyltransferase small subunit b results in neurodegeneration.
Zhao L | Spassieva S | Gable K | Gupta SD | Shi LY | Wang J | Bielawski J | Hicks WL | Krebs MP | Naggert J | Hannun YA | Dunn TM | Nishina PM
Proceedings of the National Academy of Sciences of the United States of America
2015 Oct 20 - Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols.
Casasampere M | Camacho L | Cingolani F | Casas J | Egido-Gabas M | Abad JL | Bedia C | Xu R | Wang K | Canals D | Hannun YA | Mao C | Fabrias G
Journal of lipid research
2015 Oct - Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes.
Shamseddine AA | Airola MV | Hannun YA
Advances in biological regulation
2015 Jan - On-tissue localization of ceramides and other sphingolipids by MALDI mass spectrometry imaging.
Jones EE | Dworski S | Canals D | Casas J | Fabrias G | Schoenling D | Levade T | Denlinger C | Hannun YA | Medin JA | Drake RR
Analytical chemistry
2014 Aug 19 - Identification and biochemical characterization of an acid sphingomyelinase-like protein from the bacterial plant pathogen Ralstonia solanacearum that hydrolyzes ATP to AMP but not sphingomyelin to ceramide.
Airola MV | Tumolo JM | Snider J | Hannun YA
PloS one
2014 - Defining a role for acid sphingomyelinase in the p38/interleukin-6 pathway.
Perry DM | Newcomb B | Adada M | Wu BX | Roddy P | Kitatani K | Siskind L | Obeid LM | Hannun YA
The Journal of biological chemistry
2014 Aug 8 - Evolving concepts in cancer therapy through targeting sphingolipid metabolism.
Truman JP | Garcia-Barros M | Obeid LM | Hannun YA
Biochimica et biophysica acta
2014 Aug - The plant decapeptide OSIP108 prevents copper-induced apoptosis in yeast and human cells.
Spincemaille P | Chandhok G | Newcomb B | Verbeek J | Vriens K | Zibert A | Schmidt H | Hannun YA | van Pelt J | Cassiman D | Cammue BP | Thevissen K
Biochimica et biophysica acta
2014 Jun - Ceramide and sphingosine-1-phosphate act as photodynamic therapy-elicited damage-associated molecular patterns: cell surface exposure.
Korbelik M | Banath J | Sun J | Canals D | Hannun YA | Separovic D
International immunopharmacology
2014 Jun - Essential roles of neutral ceramidase and sphingosine in mitochondrial dysfunction due to traumatic brain injury.
Novgorodov SA | Riley CL | Yu J | Borg KT | Hannun YA | Proia RL | Kindy MS | Gudz TI
The Journal of biological chemistry
2014 May 9 - Sphingolipids in colon cancer.
Garcia-Barros M | Coant N | Truman JP | Snider AJ | Hannun YA
Biochimica et biophysica acta
2014 May - Sphingolipid regulation of ezrin, radixin, and moesin proteins family: implications for cell dynamics.
Adada M | Canals D | Hannun YA | Obeid LM
Biochimica et biophysica acta
2014 May - Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation.
Wei J | Ferron M | Clarke CJ | Hannun YA | Jiang H | Blaner WS | Karsenty G
The Journal of clinical investigation
2014 Apr 1 - Sphingolipid signalling mediates mitochondrial dysfunctions and reduced chronological lifespan in the yeast model of Niemann-Pick type C1.
Vilaca R | Silva E | Nadais A | Teixeira V | Matmati N | Gaifem J | Hannun YA | Sa Miranda MC | Costa V
Molecular microbiology
2014 Feb - Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.
Bai A | Szulc ZM | Bielawski J | Pierce JS | Rembiesa B | Terzieva S | Mao C | Xu R | Wu B | Clarke CJ | Newcomb B | Liu X | Norris J | Hannun YA | Bielawska A
Bioorganic & medicinal chemistry
2014 Dec 15 - Distinct roles for hematopoietic and extra-hematopoietic sphingosine kinase-1 in inflammatory bowel disease.
Snider AJ | Ali WH | Sticca JA | Coant N | Ghaleb AM | Kawamori T | Yang VW | Hannun YA | Obeid LM
PloS one
2014 - Go-6976 reverses hyperglycemia-induced insulin resistance independently of cPKC inhibition in adipocytes.
Robinson KA | Hegyi K | Hannun YA | Buse MG | Sethi JK
PloS one
2014 - Finding pathway-modulating genes from a novel Ontology Fingerprint-derived gene network.
Qin T | Matmati N | Tsoi LC | Mohanty BK | Gao N | Tang J | Lawson AB | Hannun YA | Zheng WJ
Nucleic acids research
2014 Oct - Sphingolipids and mitochondrial function in budding yeast.
Spincemaille P | Matmati N | Hannun YA | Cammue BP | Thevissen K
Biochimica et biophysica acta
2014 Oct - The yeast sphingolipid signaling landscape.
Montefusco DJ | Matmati N | Hannun YA
Chemistry and physics of lipids
2014 Jan - The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae.
Swinnen E | Wilms T | Idkowiak-Baldys J | Smets B | De Snijder P | Accardo S | Ghillebert R | Thevissen K | Cammue B | De Vos D | Bielawski J | Hannun YA | Winderickx J
Molecular biology of the cell
2014 Jan - Sustained PKCbetaII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner.
El Osta M | Liu M | Adada M | Senkal CE | Idkowiak-Baldys J | Obeid LM | Clarke CJ | Hannun YA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2014 Jan - Sphingosine kinase 1 regulates tumor necrosis factor-mediated RANTES induction through p38 mitogen-activated protein kinase but independently of nuclear factor kappaB activation.
Adada MM | Orr-Gandy KA | Snider AJ | Canals D | Hannun YA | Obeid LM | Clarke CJ
The Journal of biological chemistry
2013 Sep 20 - A signaling cascade mediated by ceramide, src and PDGFRbeta coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1.
Cinq-Frais C | Coatrieux C | Grazide MH | Hannun YA | Negre-Salvayre A | Salvayre R | Auge N
Biochimica et biophysica acta
2013 Aug - Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation.
Orr Gandy KA | Adada M | Canals D | Carroll B | Roddy P | Hannun YA | Obeid LM
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2013 Aug - Identification of C18:1-phytoceramide as the candidate lipid mediator for hydroxyurea resistance in yeast.
Matmati N | Metelli A | Tripathi K | Yan S | Mohanty BK | Hannun YA
The Journal of biological chemistry
2013 Jun 14 - Coordination of rapid sphingolipid responses to heat stress in yeast.
Chen PW | Fonseca LL | Hannun YA | Voit EO
PLoS computational biology
2013 - Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1.
Kajimura D | Lee HW | Riley KJ | Arteaga-Solis E | Ferron M | Zhou B | Clarke CJ | Hannun YA | DePinho RA | Guo XE | Mann JJ | Karsenty G
Cell metabolism
2013 Jun 4 - Novel chemotherapeutic drugs in sphingolipid cancer research.
Canals D | Hannun YA
Handbook of experimental pharmacology
2013 - Sphingolipid metabolism and neutral sphingomyelinases.
Airola MV | Hannun YA
Handbook of experimental pharmacology
2013 - Effect of sphingosine kinase 1 inhibition on blood pressure.
Furuya H | Wada M | Shimizu Y | Yamada PM | Hannun YA | Obeid LM | Kawamori T
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2013 Feb - Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins.
Gandy KA | Canals D | Adada M | Wada M | Roddy P | Snider AJ | Hannun YA | Obeid LM
The Biochemical journal
2013 Feb 1 - Sphingosine-1-phosphate receptor 2.
Adada M | Canals D | Hannun YA | Obeid LM
The FEBS journal
2013 Dec - Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis.
Jenkins RW | Clarke CJ | Lucas JT Jr | Shabbir M | Wu BX | Simbari F | Mueller J | Hannun YA | Lazarchick J | Shirai K
American journal of hematology
2013 Nov - Sustained activation of protein kinase C induces delayed phosphorylation and regulates the fate of epidermal growth factor receptor.
Liu M | Idkowiak-Baldys J | Roddy PL | Baldys A | Raymond J | Clarke CJ | Hannun YA
PloS one
2013 - Distinct signaling roles of ceramide species in yeast revealed through systematic perturbation and systems biology analyses.
Montefusco DJ | Chen L | Matmati N | Lu S | Newcomb B | Cooper GF | Hannun YA | Lu X
Science signaling
2013 Oct 29 - Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages.
Jin J | Zhang X | Lu Z | Perry DM | Li Y | Russo SB | Cowart LA | Hannun YA | Huang Y
American journal of physiology. Endocrinology and metabolism
2013 Oct 1 - Oncogenic K-Ras regulates bioactive sphingolipids in a sphingosine kinase 1-dependent manner.
Gault CR | Eblen ST | Neumann CA | Hannun YA | Obeid LM
The Journal of biological chemistry
2012 Sep 14 - Identification and characterization of protein phosphatase 2C activation by ceramide.
Perry DM | Kitatani K | Roddy P | El-Osta M | Hannun YA
Journal of lipid research
2012 Aug - Safety study of adeno-associated virus serotype 2-mediated human acid sphingomyelinase expression in the nonhuman primate brain.
Salegio EA | Samaranch L | Jenkins RW | Clarke CJ | Lamarre C | Beyer J | Kells AP | Bringas J | Sebastian WS | Richardson RM | Rosenbluth KH | Hannun YA | Bankiewicz KS | Forsayeth J
Human gene therapy
2012 Aug - The roles of neutral sphingomyelinases in neurological pathologies.
Horres CR | Hannun YA
Neurochemical research
2012 Jun - Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release.
Truman JP | Al Gadban MM | Smith KJ | Jenkins RW | Mayroo N | Virella G | Lopes-Virella MF | Bielawska A | Hannun YA | Hammad SM
Immunology
2012 May - Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction.
Meyers-Needham M | Lewis JA | Gencer S | Sentelle RD | Saddoughi SA | Clarke CJ | Hannun YA | Norell H | da Palma TM | Nishimura M | Kraveka JM | Khavandgar Z | Murshed M | Cevik MO | Ogretmen B
Molecular cancer therapeutics
2012 May - Dihydroceramide accumulation and reactive oxygen species are distinct and nonessential events in 4-HPR-mediated leukemia cell death.
Apraiz A | Idkowiak-Baldys J | Nieto-Rementeria N | Boyano MD | Hannun YA | Asumendi A
Biochemistry and cell biology = Biochimie et biologie cellulaire
2012 Apr - The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans.
Thevissen K | de Mello Tavares P | Xu D | Blankenship J | Vandenbosch D | Idkowiak-Baldys J | Govaert G | Bink A | Rozental S | de Groot PW | Davis TR | Kumamoto CA | Vargas G | Nimrichter L | Coenye T | Mitchell A | Roemer T | Hannun YA | Cammue BP
Molecular microbiology
2012 Apr - Defining a role for sphingosine kinase 1 in p53-dependent tumors.
Heffernan-Stroud LA | Helke KL | Jenkins RW | De Costa AM | Hannun YA | Obeid LM
Oncogene
2012 Mar 1 - Protein phosphatase 1alpha mediates ceramide-induced ERM protein dephosphorylation: a novel mechanism independent of phosphatidylinositol 4, 5-biphosphate (PIP2) and myosin/ERM phosphatase.
Canals D | Roddy P | Hannun YA
The Journal of biological chemistry
2012 Mar 23 - Sphingoid bases and the serine catabolic enzyme CHA1 define a novel feedforward/feedback mechanism in the response to serine availability.
Montefusco DJ | Newcomb B | Gandy JL | Brice SE | Matmati N | Cowart LA | Hannun YA
The Journal of biological chemistry
2012 Mar 16 - Ceramide synthases at the centre of sphingolipid metabolism and biology.
Mullen TD | Hannun YA | Obeid LM
The Biochemical journal
2012 Feb 1 - Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.
Snider AJ | Wu BX | Jenkins RW | Sticca JA | Kawamori T | Hannun YA | Obeid LM
Prostaglandins & other lipid mediators
2012 Dec - Modulation of mitochondrial outer membrane permeabilization and apoptosis by ceramide metabolism.
Rego A | Costa M | Chaves SR | Matmati N | Pereira H | Sousa MJ | Moradas-Ferreira P | Hannun YA | Costa V | Corte-Real M
PloS one
2012 - Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition.
Sewell GW | Hannun YA | Han X | Koster G | Bielawski J | Goss V | Smith PJ | Rahman FZ | Vega R | Bloom SL | Walker AP | Postle AD | Segal AW
The international journal of biochemistry & cell biology
2012 Nov - Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B.
Beckham TH | Lu P | Cheng JC | Zhao D | Turner LS | Zhang X | Hoffman S | Armeson KE | Liu A | Marrison T | Hannun YA | Liu X
International journal of cancer. Journal international du cancer
2012 Nov 1 - Results of a phase II trial of gemcitabine plus doxorubicin in patients with recurrent head and neck cancers: serum C(1)(8)-ceramide as a novel biomarker for monitoring response.
Saddoughi SA | Garrett-Mayer E | Chaudhary U | O'Brien PE | Afrin LB | Day TA | Gillespie MB | Sharma AK | Wilhoit CS | Bostick R | Senkal CE | Hannun YA | Bielawski J | Simon GR | Shirai K | Ogretmen B
Clinical cancer research : an official journal of the American Association for Cancer Research
2011 Sep 15 - Many ceramides.
Hannun YA | Obeid LM
The Journal of biological chemistry
2011 Aug 12 - Identification of dihydroceramide desaturase as a direct in vitro target for fenretinide.
Rahmaniyan M | Curley RW Jr | Obeid LM | Hannun YA | Kraveka JM
The Journal of biological chemistry
2011 Jul 15 - Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA.
Novgorodov SA | Wu BX | Gudz TI | Bielawski J | Ovchinnikova TV | Hannun YA | Obeid LM
The Journal of biological chemistry
2011 Jul 15 - A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization.
Khavandgar Z | Poirier C | Clarke CJ | Li J | Wang N | McKee MD | Hannun YA | Murshed M
The Journal of cell biology
2011 Jul 25 - Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells.
Barbosa AD | Osorio H | Sims KJ | Almeida T | Alves M | Bielawski J | Amorim MA | Moradas-Ferreira P | Hannun YA | Costa V
Molecular microbiology
2011 Jul - Identification of novel anionic phospholipid binding domains in neutral sphingomyelinase 2 with selective binding preference.
Wu BX | Clarke CJ | Matmati N | Montefusco D | Bartke N | Hannun YA
The Journal of biological chemistry
2011 Jun 24 - Neutral sphingomyelinase-2 mediates growth arrest by retinoic acid through modulation of ribosomal S6 kinase.
Clarke CJ | Mediwala K | Jenkins RW | Sutton CA | Tholanikunnel BG | Hannun YA
The Journal of biological chemistry
2011 Jun 17 - Delayed phosphorylation of classical protein kinase C (PKC) substrates requires PKC internalization and formation of the pericentrion in a phospholipase D (PLD)-dependent manner.
El-Osta MA | Idkowiak-Baldys J | Hannun YA
The Journal of biological chemistry
2011 Jun 3 - Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction.
Hernandez-Corbacho MJ | Jenkins RW | Clarke CJ | Hannun YA | Obeid LM | Snider AJ | Siskind LJ
PloS one
2011 - Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases.
Canals D | Perry DM | Jenkins RW | Hannun YA
British journal of pharmacology
2011 Jun - Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events.
Mullen TD | Jenkins RW | Clarke CJ | Bielawski J | Hannun YA | Obeid LM
The Journal of biological chemistry
2011 May 6 - A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation.
Zhao L | Spassieva SD | Jucius TJ | Shultz LD | Shick HE | Macklin WB | Hannun YA | Obeid LM | Ackerman SL
PLoS genetics
2011 May - Isofagomine in vivo effects in a neuronopathic Gaucher disease mouse.
Sun Y | Ran H | Liou B | Quinn B | Zamzow M | Zhang W | Bielawski J | Kitatani K | Setchell KD | Hannun YA | Grabowski GA
PloS one
2011 - Purification and characterization of a second type of neutral ceramidase from rat brain: a second more hydrophobic form of rat brain ceramidase.
Thayyullathil F | Chathoth S | Hago A | Patel M | Szulc ZM | Hannun Y | Galadari S
Biochimica et biophysica acta
2011 Apr - Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.
Jenkins RW | Clarke CJ | Canals D | Snider AJ | Gault CR | Heffernan-Stroud L | Wu BX | Simbari F | Roddy P | Kitatani K | Obeid LM | Hannun YA
The Journal of biological chemistry
2011 Apr 15 - Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-alpha in MCF-7 cells.
Clarke CJ | Cloessner EA | Roddy PL | Hannun YA
The Biochemical journal
2011 Apr 15 - The neutral sphingomyelinase family: identifying biochemical connections.
Clarke CJ | Wu BX | Hannun YA
Advances in enzyme regulation
2011 - A role of sphingosine kinase 1 in head and neck carcinogenesis.
Shirai K | Kaneshiro T | Wada M | Furuya H | Bielawski J | Hannun YA | Obeid LM | Ogretmen B | Kawamori T
Cancer prevention research (Philadelphia, Pa.)
2011 Mar - Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine.
An D | Na C | Bielawski J | Hannun YA | Kasper DL
Proceedings of the National Academy of Sciences of the United States of America
2011 Mar 15 - Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis.
Hou Q | Jin J | Zhou H | Novgorodov SA | Bielawska A | Szulc ZM | Hannun YA | Obeid LM | Hsu YT
Journal of lipid research
2011 Feb
Expertise
Education
- Fellowship: Duke University Medical Center, IM-Hematology/Oncol, 1985
- Residency: American University of Beirut Medical Center, Internal Medicine, 1983
- Medical School: American University of Beirut Medical Center, 1981
